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KMID : 0359920110300060647
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Korean Journal of Nephrology
2011 Volume.30 No. 6 p.647 ~ p.650
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Severe Symptomatic Hyponatremia Caused by Low Dose Oral Cyclophosphamide: A Case Report
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Park Seung-Kyo
Kim Woo-Jeung
Choi Hoon-Young
Ha Sung-Kyu
Yoon Ji-Hyun
Park Hyeong-Cheon
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Abstract
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Cyclophosphamide (CY), an alkylating agent, is frequently used in the treatment of various autoimmune disorders and malignancies. Acute hyponatremia is a well-known side effect of moderate to high dose intravenous CY treatment, but is rare in patients treated with low dose intravenous CY. We report the case of a severe symptomatic hyponatremia in a 68-year-old woman with renal impairment who was treated with oral CY (100 mg/day) for anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (GN). This case demonstrates that even oral CY could be associated with life threatening acute hyponatremia and should be used with caution.
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KEYWORD
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Hyponatremia, Cyclophosphamide, ANCA associated vasculitis
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